Figure 1.

Sound Causes Upward FP Deflections in V1 that Are Accompanied by Cellular Hyperpolarizations

(A) The grand average ± SEM of FP responses recorded in lightly anesthetized (n = 12) and awake, head-restrained (n = 3), and freely moving (n = 6) mice. Dashed lines are stimulus onsets.

(B) Left: examples of individual FP recordings (black) aligned with the onset of a noise burst, averaged over 50 presentations (red). Right: change of spectral content over time relative to the baseline (1 s) of the averaged FP response.

(C) Same plot as in B for individual trials (left) and intertrial coherence, measured as the phase-locking factor between trials (right). Note the prominent gamma band after the SH.

(D) Examples of simultaneous FP and whole cell (WC) recordings of the V_m from a L2/3P in V1. Magnified SHs are depicted in gray.

(E) Overlaid FP and V_m responses of a L2/3P in an awake mouse. Upward FP responses reflect hyperpolarizations.

(F) Intensity response of SHs. Examples of V_m (top) and FP (bottom) responses for different sound intensities. The response was barely detectable for 48 dB SPL sound intensity and quickly reached a saturating plateau for sound intensities > 64 dB SPL (^∗p < 0.05 for post hoc tests). Error bars in right plot are SEMs. The gray band depicts the detection level (>baseline ± 2 SD).

See also Figure S1.