Figure 2.

Voxel-based morphometry analysis

Clusters of significant grey-matter atrophy in a cohort of ten patients with amyotrophic lateral sclerosis (ALS) and the pathological expanded C9orf72 hexanucleotide repeat compared with 30 matched patients with ALS without the repeat expansion. The four columns show the four clusters (from left to right: in the right inferior frontal gyrus, right superior frontal gyrus, left anterior cingulate gyrus, and the right precentral gyrus) in the three main radiological planes in each row (top to bottom: axial, coronal, saggital). R=right hemisphere. L=left hemisphere.