Figure 4.

Monocyte-derived MPs induce cytokine production in monocytes (A) and MDM (B). Concentration-dependent (1–30 µg·mL⁻¹) effects of MPs and modulation by PPARγ agonists (15d-PGJ₂ (15d-PGJ; 10 µM), rosiglitazone (Rosi, 1 µM) and antagonist (GW9662, 1 µM). TNF-α and IL-6 release by PMA 10⁻⁷ M are shown for comparison. Values are mean ± SEM; n = 5. *P < 0.05 versus TNF-α; **P < 0.01 versus TNF-α; °°P < 0.01 versus MPs 10 µg·mL⁻¹; °P < 0.05 versus MPs 10 µg·mL⁻¹.