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Monocyte-derived MPs induce NF-κB activation in human monocytes (A) and MDM (B). Concentration-dependent (1–30 µg·mL−1) effects of MPs and modulation by rosiglitazone (Rosi, 5 µM) and a PPARγ antagonist (GW9662, 1 µM). The effects produced by PMA 1 µM are shown for comparison. Histograms below each blot are densitometric analysis for EMSA quantification, control, unstimulated cells being = 1. Mean ± SEM; n = 4. *P < 0.05 versus control.
