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. Author manuscript; available in PMC: 2012 Mar 29.

Published in final edited form as: Pharmacol Biochem Behav. 2011 Dec 9;101(1):62–68. doi: 10.1016/j.pbb.2011.12.001

Fig. 3 — Effect of intra-CeA administration of the α2-adrenergic receptor agonist clonidine on elevations in ICSS thresholds associated with precipitated nicotine withdrawal (A; saline, n = 8; nicotine, n = 13). Effect of intra-CeA clonidine on the response latencies of rats chronically treated with saline or nicotine and acutely treated with mecamylamine (B; saline n = 8, nicotine n = 13). ICSS thresholds and response latencies are expressed as a percentage of the pre-test day values. Clonidine was administered bilaterally and the figures depict the unilateral dose. Abbreviation: ic, intracranial.

Fig. 3 — Effect of intra-CeA administration of the α2-adrenergic receptor agonist clonidine on elevations in ICSS thresholds associated with precipitated nicotine withdrawal (A; saline, n = 8; nicotine, n = 13). Effect of intra-CeA clonidine on the response latencies of rats chronically treated with saline or nicotine and acutely treated with mecamylamine (B; saline n = 8, nicotine n = 13). ICSS thresholds and response latencies are expressed as a percentage of the pre-test day values. Clonidine was administered bilaterally and the figures depict the unilateral dose. Abbreviation: ic, intracranial.