Table 1.

Absolute baseline brain reward thresholds and response latencies.

	Thresholds (μA)		Latencies (s)
	Saline	Nicotine	Saline	Nicotine
Exp. 1A R278995/CRA0450-CeA (saline, n = 9; nicotine, n = 8)
Prior pump implantation	123.3 ± 14.5	119.0 ± 13.2	3.1 ± 0.1	3.0 ± 0.2
Prior first injection	113.8 ± 15.3	108.8 ± 13.4	3.2 ± 0.2	3.0 ± 0.2
Exp. 1B R278995/CRA0450-BLA (nicotine, n = 6)
Prior pump implantation	N/A	85.8 ± 9.3	N/A	3.5 ± 0.1
Prior first injection	N/A	82.7 ± 11.3	N/A	2.9 ± 0.1
Exp. 2 Prazosin-CeA (saline, n = 10; nicotine, n = 10)
Prior pump implantation	96.3 ± 7.1	88.8 ± 8.5	3.3 ± 0.1	3.3 ± 0.1
Prior first injection	100.2 ± 6.6	94.4 ± 8.9	3.5 ± 0.1	3.4 ± 0.1
Exp. 3 Clonidine-CeA (saline, n = 8; nicotine, n = 13)
Prior pump implantation	100.7 ± 7.7	112.5 ± 10.6	3.1 ± 0.1	3.6 ± 0.2*
Prior first injection	101.1 ± 8.1	115.7 ± 11.4	3.2 ± 0.1	3.5 ± 0.2

Prior refers to the test-day immediately before the implantation of the osomotic minipumps or the start of the mecamylamine injections. Asterisk (P<0.05) indicates that the latency of the nicotine group is longer than the latency of the saline group. Abbreviations: CeA, central nucleus of the amygdala; BLA, basolateral nucleus of the amygdala.