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. Author manuscript; available in PMC: 2012 Mar 29.
Published in final edited form as: Angew Chem Int Ed Engl. 2011 Jun 30;50(34):7915–7918. doi: 10.1002/anie.201102941

Figure 1.

Figure 1

Detection principles of AuNP immunosensors. The sensor surface after protein capture is shown on the left in the center. On the bottom left is a tapping-mode AFM image of a AuNP film that serves as the immunosensor platform. A) The immunosensor after treatment with biotinylated Ab2 followed by streptavidin-modified HRP resulting in HRP–Ab2 and providing 14–16 labels per binding event. B) The immunosensor after treatment with massively labeled Ab2–MB–HRP particles to obtain amplification by providing around 500000 enzyme labels per binding event.