Table 2.
Sensitivity and resistance of human CRC cell lines to mTOR inhibitors
| Rapamycin | BEZ235 | PP242 | WYE354 | |
| CACO2 | − | − | − | − |
| COLO205 | + | + | + | + |
| DLD1 | − | − | + | + |
| HCT116 | + | + | + | + |
| HT29 | + | +/− | + | + |
| KM12 | + | − | − | − |
| LOVO | + | − | − | − |
| RKO | + | − | +/− | − |
| SW1116 | + | + | +/− | +/− |
| SW48 | + | − | − | − |
| SW620 | + | + | + | + |
| SW480 | + | − | − | − |
Summary of the inhibitory effect of mTOR inhibitors on 12 human colorectal cancer cell lines as judged by growth inhibition using the optimized sulforhodamine B (SRB) assay. +, drug-resistant; −, drug-sensitive; +/−, partially drug-sensitive.