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. Author manuscript; available in PMC: 2012 Mar 29.
Published in final edited form as: Neuroscience. 2010 Feb 24;167(3):786–798. doi: 10.1016/j.neuroscience.2010.02.037

Fig. 2.

Fig. 2

Developmental changes of CaV subunit mRNA expression in cortex and hippocampus. CaV subunit expression profiles were determined in embryonic (E16), postnatal (PD1), and 2 and 8 weeks old BALB/c mice. (A) During development cortical mRNA levels of CaV1.2, CaV2.2, CaV2.3, β1, β3, and α2δ-2 significantly decline, whereas levels of β2 and β4 increase. Levels of CaV1.3, CaV2.1, and α2δ-1 and α2δ-3 remain stable. (B) In hippocampus the overall developmental changes are less striking than in cortex. However, the increase in β2 and the significant drop of β3 levels between E16 and PD1 are more pronounced. In contrast to whole cortex, levels of CaV2.3 did not decline. Although total mRNA levels are negligible in comparison with the other α2δ subunits, expression of α2δ-4 increases ~20-fold during development. * P<0.05; ** P<0.01; 2-way ANOVA plus post hoc ANOVA with Holm correction; error bars: ±SEM.