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. 2012 Apr;139(4):285–294. doi: 10.1085/jgp.201110764

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© 2012 Cenedese et al.

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Figure 5. — Activation and deactivation kinetics of TMEM16B. (A) Representative recordings at the indicated [Ca²⁺]_i. Voltage protocol as in Fig. 1 A, with voltage steps from a holding voltage of 0 between +40 to +100 mV in 20-mV steps. Red dashed lines are the fit to a single-exponential function. (B) Average activation time constants (τ_act) plotted versus voltage (n = 6–8). (C) Representative recordings at the indicated [Ca²⁺]_i. Voltage protocol as in Fig. 1 C, with a prepulse to +100 mV and tail currents induced by voltage steps between −100 and +100 mV in 20-mV steps. Only tail currents are illustrated. Red dashed lines are the fit to a single-exponential function. (D) Average deactivation time constants (τ_deact) plotted versus voltage (n = 4–9).