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. 2012 Apr;139(4):295–304. doi: 10.1085/jgp.201110725

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© 2012 Tan et al.

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Figure 7. — Inhibition of L70A/tL70Y homo- and heterochannels by external TEA. (A) Electrophoretical separation of five homo- and heterotetramers formed by coexpressing L70A and tL70Y proteins on the 12.5% SDS–polyacrylamide gel. (B) Current traces for L70A/tL70Y co-tetramers with five-subunit combinations (−60 mV). For each tetramer, the top trace was recorded without TEA and the bottom one with the external TEA around IC₅₀. (C) TEA concentration–dependent inhibition fraction for the five L70A/tL70Y co-tetramers. Data points are presented as mean ± SD. (D) TEA binding energy ΔG for each type of L70A/tL70Y co-tetramer, as calculated from IC₅₀.