Table 3.
Demographic and Disease Characteristics of First- and Second-Generation Patients Among Parent-Offspring Familial Nonmedullary Thyroid Carcinoma
| Parameters | First generation (n=43) | Second generation (n=75) | p |
|---|---|---|---|
| Age at diagnosis (years) | 57±11 | 38±12 | <0.0001 |
| Female sex rate (%) | 83.7% | 77.3% | 0.407 |
| Histopathology (% of papillary carcinoma) | 95.3 | 93.2 | 0.631 |
| Tumor size (cm) | 1.4±1.4 | 1.2±0.8 | 0.499 |
| LN metastasis (%) | 27.9 | 41.3 | 0.270 |
| Multifocality (%) | 37.2 | 40.0 | 0.765 |
| Extrathyroidal invasion (%) | 29.4 | 58.5 | 0.006 |
| Combined chronic thyroiditis (%) | 25.0 | 23.9 | 0.889 |
| TNM staging (%)a | 35.1/8.1/56.8/0.0 | 73.0/4.8/22.2/0.0 | 0.014 |
| T staging (%)b | 34.3/5.7/60.0/0.0 | 30.6/8.1/61.3/0.0 | 0.874 |
| N staging (%)c | 63.3/36.4 | 53.6/46.4 | 0.383 |
| M staging (%)d | 100.0/0.0 | 98.7/1.3 | 0.447 |
| ATA riske | 75.0/22.2/2.8 | 43.9/53.0/3.0 | 0.009 |
| Recurrence rate (%) | 19.0 | 50.0 | 0.030 |
a
Stage 1/2/3/4 rate.
b
T 1/2/3/4.
c
N 0/1.
d
M 0/1.
e
ATA recurrence risk stratification, low/intermediate/high risk rate.