Table 4.

FK506 Pharmacokinetics of Each Subgroup at Different Time Points

		Sampling time
Parameters	Subgroup	Day 1	Day 15	Day 30
Cmax	Cn	4.306±0.785 ng·mL−1	6.95±2.99 ng·mL−1	4.31±0.78 ng·mL−1
	Cc	6.23±1.23 ng·mL−1	6.45±3.07 ng·mL−1	6.85±2.37 ng·mL−1
	Dn	5.62±2.01 ng·mL−1*	12.31±3.88 ng·mL−1	8.49±5.91 ng·mL−1
	DC	6.98±3.25 ng·mL−1	9.00±4.83 ng·mL−1	9.15±3.45 ng·mL−1
	En	6.29±1.88 ng·mL−1*	11.02±4.93 ng·mL−1	7.24±3.61 ng·h·mL−1
	EC	7.34±4.34 ng·mL−1	14.89±6.85 ng·mL−1	10.85±7.94 ng·h·mL−1
t½	Cn	4.36±1.32 h	4.24±2.08 h	4.29±1.55 h
	Cc	6.54±1.82 h	6.36±2.82 h	6.29±1.34 h
	Dn	4.41±2.96 h	4.56±2.81 h	7.73±1.31 h
	DC	7.13±1.96 h	7.56±1.96 h	6.73±1.31 h
	En	3.75±1.35 h	4.73±2.92 h	7.77±1.23 h
	EC	7.12±3.35 h	8.12±3.35 h	6.77±1.23 h
AUC0-t	Cn	27.189±11.36 ng·h·mL−1	32.08±13.21 ng·h·mL−1	32.56±13.27 ng·h·mL−1
	Cc	28.654±13.36 ng·h·mL−1	27.97±14.32 ng·h·mL−1	24.00±13.04 ng·h·mL−1
	Dn	36.25±6.15 ng·h·mL−1	44.33±15.44 ng·h·mL−1	39.12±9.15 ng·h·mL−1
	DC	37.54±7.75 ng·h·mL−1	40.66±22.90 ng·h·mL−1	39.13±22.54 ng·h·mL−1
	En	38.17±7.61 ng·h·mL−1	72.08±117.96 ng·h·mL−1	25.01±12.24 ng·h·mL−1
	EC	39.27±5.61 ng·h·mL−1	48.09±31.22 ng·h·mL−1	47.23±36.01 ng·h·mL−1
AUC0-∞	Cn	20.95±7.19 ng·h·mL−1	47.92±19.11 ng·h·mL−1	47.98±15.00 ng·h·mL−1
	Cc	25.77±18.56 ng·h·mL−1*	34.95±7.19 ng·h·mL−1	50.98±15.00 ng·h·mL−1
	Dn	19.17±6.99 ng·h·mL−1*	91.11±14.69 ng·h·mL−1	31.79±18.14 ng·h·mL−1
	DC	26.59±13.23 ng·h·mL−1	48.17±31.99 ng·h·mL−1	52.79±18.14 ng·h·mL−1
	En	19.50±3.65 ng·h·mL−1*	97.40±16.39 ng·h·mL−1	37.35±10.61 ng·h·mL−1
	EC	30.50±18.54 ng·h·mL−1	70.50±42.65 ng·h·mL−1	67.35±10.61 ng·h·mL−1

A significant difference in C_max and AUC_0-∞ was observed between normal and corneal transplant groups on say 1 (p<0.05).

n, Normal; c, corneal transplantation; C_n, C_c, high dose; D_n, D_c, medium dose; E_n, E_c, low dose.