TABLE 1.
Estimates of MULTISIG1 model parameters, variables, and functions based on data for γ-H2AX foci per cell.a
| Parameter, Variable, or Function | Estimate |
|---|---|
| RB(t, D) | Ft: experimentally determined average residual γ-H2AX foci per cell at time t after exposure to dose D |
| BT | Fmin: minimum of measured values for average γ-H2AX foci per cell at late times after exposure when repair is completed |
| α | Calculated slope of the dose-response curve for average γ-H2AX foci per cell obtained shortly after exposure (before repair occurs) |
| B0 | F0: observed average spontaneous γ-H2AX foci per cell |
| T | d = (Fmin- F0)/slope |
| β | b = - t / ln{(Ft– Fmin) / [slope (D - d)]} |
| μ | b−1 |
| Repair halftime | b ln (2) |
a
Estimates of model parameters can also be obtained by fitting the MULTISIG1 model to dose-response data for γ-H2AX foci per cell using a Bayesian approach.