Table 1.

Selected U.S. Milestones in the Evolution of Cumulative Risk Assessment for Health Effects from Exposure to Chemical Mixtures.

Year	Milestone	Reference(s)
1986	U.S. Environmental Protection Agency: Guidelines for the Health Risk Assessment of Chemical Mixtures	[8]
1993	National Research Council/National Academy of Sciences: Pesticides in the Diets of Infants and Children	[44]
1996	U.S. Federal Law (special protection for children from cumulative risk of pesticides in food): Food Quality Protection Act	[45]
1996	U.S. Federal Law (cumulative risk analysis for chemical mixtures in drinking water): Amendments to the Safe Drinking Water Act	[46]
1999	International Life Sciences Institute: A Framework for Cumulative Risk Assessment	[17]
2000	U.S. Environmental Protection Agency: Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures	[9]
2002	U.S. Environmental Protection Agency: Organophosphate Pesticides: Revised Cumulative Risk Assessment	[18]
2002	U.S. Environmental Protection Agency: National-scale Air Toxics Assessment (updated in 2006, 2009, 2011)	[48,49,50,51]
2004	Agency for Toxic Substances and Disease Registry: Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures	[19]
2006	U.S. Environmental Protection Agency: Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effects	[10]
2007	U.S. Environmental Protection Agency: Concepts, Methods, and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects: A Resource Document	[52]
2008	National Research Council/National Academy of Sciences: Phthalates and Cumulative Risk Assessment	[39]
2009	Minnesota Pollution Control Agency: Cumulative Air Emissions Risk Analysis at the MPCA – Background Document	[53]
2010	International Journal of Toxicology: collection of articles on cumulative risk assessment for chemicals	[54,55,56,57,58]