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ENK elevations in hAPPFAD mice correlate with calbindin depletions in the dentate gyrus. A, B, Horizontal brain sections of 2- to 4-month-old (A) and 6-month-old (B) hAPPFAD mice (J20 line) were immunostained for ENK and calbindin, and immunoreactivities were quantitated by densitometry. ENK elevations in the hilus correlated with calbindin depletions in the outer molecular layer in hAPPFAD mice. R2 and p values refer to hAPPFAD mice only.
