Figure 7.
Tau reduction prevents ENK elevations in hAPPFAD mice from line J20. Mice were analyzed at 5–7 months of age. A, Coronal sections of the hippocampus immunostained for ENK. B, C, ENK immunoreactivity in the hilus (B) and mossy fibers (C) was quantitated densitometrically in the groups indicated [n = 7–10 mice per genotype, except for hAPPFAD/Tau+/+ mice (n = 3)]. Two-way ANOVA revealed a significant APP effect (p < 0.001), Tau effect (p < 0.05), and APP × Tau interaction (p < 0.01) for both regions. **p < 0.01 versus Tau+/+ mice without hAPP (Dunnett's test); +p < 0.05, ++p < 0.01 versus Tau+/+ mice with hAPP (Fisher's PLSD test). Values are mean ± SEM.