Table 1.

List of genes found in the 16 computed deregulated subgraphs of sizes 10–25 and number of occurrences for BRCA1 mutation carriers versus non-mutation carriers

Gene ID	Gene symbol	Gene description	Number of occurrences in the 16 deregulated subgraphs
7157	TP53	Tumor protein p53	16
6241	RRM2	Ribonucleotide reductase M2	16
5603	MAPK13	Mitogen-activated protein kinase 13	16
4616	GADD45B	Growth arrest and DNA damage-inducible, beta	16
1649	DDIT3	DN damage-inducible transcript 3	16
7422	VEGFA	Vascular endothelial growth factor A	16
3791	KDR	Kinase insert domain receptor (a type III receptor tyrosine kinase)	16
2034	EPAS1	Endothelial PAS domain protein 1	16
112 399	EGLN3	egl nine homolog 3 (Caenorhabditis elegans)	16
83 667	SESN2	Sestrin 2	15
998	CDC42	Cell division cycle 42 (GTP binding protein, 25 kD)	15
8503	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	14
5063	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	13
3576	IL8	Interleukin 8	11
5837	PYGM	Phosphorylase, glycogen, muscle	9
51 806	CALML5	Calmodulin-like 5	9
5507	PPP1R3C	Protein phosphatase 1, regulatory (inhibitor) subunit 3C	9
10 000	AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	9
891	CCNB1	Cyclin B1	8
5533	PPP3CC	Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform	5
7043	TGFB3	Transforming growth factor, beta 3	5
3725	JUN	Jun oncogene	2
8399	PLA2G10	Phospholipase A2, group X	1
5879	RAC1	Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	1
5608	MAP2K6	Mitogen-activated protein kinase kinase 6	1
5602	MAPK10	Mitogen-activated protein kinase 10	1
5595	MAPK3	Mitogen-activated protein kinase 3	1
5106	PCK2	Phosphoenolpyruvate carboxykinase 2 (mitochondrial)	1
50 487	PLA2G3	Phospholipase A2, group III	1
399 694	SHC4	SHC (Src homology 2 domain containing) family, member 4	1
2353	FOS	FBJ murine osteosarcoma viral oncogene homolog	1
2308	FOXO1	Forkhead box O1	1
9047	SH2D2A	SH2 domain protein 2A	1
5747	PTK2	PTK2 protein tyrosine kinase 2	1