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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: J Am Chem Soc. 2012 Feb 15;134(8):3917–3924. doi: 10.1021/ja300044e

Table 2.

Direct strand scission under anaerobic conditions from 5,6-dihydrouridin-5-yl (1).

Absolute yield (%)a
Substrateb Inter.c Intra.d Total % Inter.c
ds U6U (16) 31.9 ± 3.0 2.0 ± 0.7 33.9 ± 3.0 94.1 ± 1.9
ss U6U (18) 3.4 ± 0.6 3.2 ± 0.2 6.9 ± 1.3 52.1 ± 13.5
ds A6A (17) 26.1 ± 3.8 2.4 ± 1.6 28.6 ± 3.5 91.3 ± 6.0
ss A6A (19) 5.4 ± 1.4 2.4 ± 0.6 8.0 ± 1.5 68.0 ± 4.5
a

Yields are the average of at least 3 separate experiments each carried out in triplicate.

b

The substrate is designated by its secondary structure (ss, ds).

c

Inter. corresponds to strand scission at the 5'-adjacent nucleotide from 6.

d

Intra. corresponds to strand scission at the nucleotide where 1 is generated.