Table 7.
Association between IL-6 haplotype CAT and LOAD by hypertension or type 2 DM
| 2 copiesa | 0 or 1 copy | pinteractionb | |||
|---|---|---|---|---|---|
| Case/Control | AOR | Case/Control | AOR (95% CI) | ||
| Hypertension | |||||
| No | 94/104 | 1.00 | 71/100 | 0.67 (0.39-1.15) | 0.49 |
| Yes | 65/139 | 1.00 | 36/100 | 0.52 (0.29-0.95) | |
| Type 2 DM | |||||
| No | 133/209 | 1.00 | 84/171 | 0.59 (0.39-0.92) | 0.36 |
| Yes | 25/33 | 1.00 | 23/29 | 0.91 (0.36-2.26) | |
Abbreviation: AOR, adjusted odds ratio; DM, diabetes mellitus; LOAD, late-onset Alzheimer's disease.
All models were adjusted for age, gender, education, and ApoE e4 status.
a 2 copies of haplotype CAT was used as the reference group because it is a major haplotype.
b pinteraction value was obtained by using the dominant model.