| I |
Enediyne |
Iteratively acting, builds typical 9 or 10 membered enedyines. |
Enediyne (calicheamicin) |
|
Trans-AT |
Module lacks cognate AT domain; this activity is provided instead by a discrete protein encoded in trans. |
Polyketide/macrolide(leinamycin) |
|
Cis-AT |
Multi-domain module that includes AT domain. |
Polyketide/macrolide (erythromycin) |
|
Hybrid |
Catalyzes a condensation reaction between an amino acid and an acyl extender unit in a NRPS/PKS pathway. |
Peptide-polyketide(microcystin) |
|
Iterative |
Domain is used multiple times in a cyclic fashion. |
Polycyclic polyketide(aflatoxin) |
|
PUFA |
Produces long chain fatty acids containing more than one double bond. |
Polyunsaturated fatty acid(omega-3-fatty-acid) |
|
KS1 |
Occurs in the first module of multimodular genes, includes typical starter KSs (KSQ) as well as KS domains that incorporate unusual precursors. |
Polyketide, peptide-polyketide(salinosporamide) |
| II |
Type II |
Each domain occurs on a discrete protein. |
Aromatic polyketide (actinorhodin) |
|
FAS |
Involved in fatty acid biosynthesis (eg., FabB and FabF from bacteria). |
Fatty acid(palmitic acid) |
