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. 2012 Mar 29;7(3):e33894. doi: 10.1371/journal.pone.0033894

Figure 3. In vivo sensitivity of ALL xenografts to VXL combination treatment.

Figure 3

Female mice were engrafted with: ALL-4 (A); ALL-7 (B); ALL-11 (C); or ALL-16 (D); and treated with a combination of VCR (0.15 mg/kg), DEX (5 mg/kg) and ASP (1000 U/kg). The %huCD45+ cells in PB of individual mice (left panel) and Kaplan-Meier analysis of EFS (right panel). Control vehicle-treated mice (dashed lines); drug-treated mice (solid lines). Shaded boxes represent the treatment period. No leukaemia related events were recorded for the drug treated group of ALL-16 engrafted mice.