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. 2012 Mar 29;7(3):e33894. doi: 10.1371/journal.pone.0033894

Figure 7. In vivo sensitivity of ALL xenografts to VXL and VXL/ATO combination treatments.

Figure 7

Female mice were engrafted with: ALL-4 (A); ALL-7 (B); ALL-8 (C); or ALL-19 (D) and treated with a diluent vehicle (controls, dashed black lines), ATO (2.5 mg/kg, solid grey lines), VXL combination (solid black lines), or VXL+ATO quadruple combination (dashed grey lines). Engraftment kinetics indicated by %huCD45+ cells in PB of individual mice (left panel) and Kaplan-Meier survival curves (EFS) (right panel) are shown. Shaded boxes represent the treatment period.