Table 1. Combination Indices of in vitro cytotoxicity assays.
VCR [ng/mL] | DEX [nM] | ASP [U/mL] | Combination Index Values | |||
CEM | COG-LL-317 | COG-LL-319 | RS4-11 | |||
0.5 | 50 | 1 | 0.15 | 0.10 | 0.10 | 0.04 |
1.25 | 125 | 2.5 | 0.33 | 0.11 | 0.11 | 0.09 |
2.5 | 250 | 5 | 0.61 | 0.15 | 0.15 | 0.16 |
5 | 500 | 10 | 1.04 | 0.21 | 0.21 | 0.10 |
VCR, vincristine; DEX, dexamethasone; ASP, l-asparaginase.