Table 3. Estimated pharmacokinetic parameters.
| ‡Parameter | Single Agent | VXL Combination |
| VCR 0.15 mg/kg | VCR 0.15 mg/kg | |
| AUC0-∞ (mg/L*min) | 1.60 | 1.75 |
| Cmax (ng/mL) | 6.2 | 8.7 |
| Tmax (h) | 1 | 0.5 |
| DEX 5 mg/kg | DEX 5 mg/kg | |
| AUC0-∞ (ng*h/mL) | 3279.05 | 6792.95 |
| Cmax (ng/mL) | 1760.73 | 2849.02 |
| Tmax (h) | 0.16 | 0.25 |
| ASP 1000 U/kg | ASP 1000 U/kg | |
| AUC0-∞ (U*h/mL) | 87.02 | 99.44 |
| Cmax (U/mL) | 8.27 | 8.90 |
| Tmax (h) | 2.21 | 1.97 |
‡
Abbreviations. AUC0-∞: Area under the concentration-time curve from zero to infinity; Cmax: actual maximum concentration observed after drug administration; Tmax: time of maximum drug concentration.