Table 1. αK i (µM) values of Chembridge compounds against IMP and NAD+, in vitro activity of Chembridge compounds against M. tuberculosis H37Rv and M. smegmatis and selectivity index (SI).
| ChemBridge I.d. | IMP K i (µM) | IMP αK i (µM) | NAD K i (µM) | NAD αK i (µM) | M. tb MIC90 (µg/ml) | SI | M. smeg MIC90 (µg/ml) |
| 5217501 | 0.548 (UC) | 0.523 (UC) | 4.83 | >8.76 | 12 | ||
| 6655281 | 16.7 (UC) | 13.9 (UC) | 3.45 | 3.66 | 0.75 | ||
| 7240597 | 101.6 (UC) | 94.1 (UC) | 10.43 | NA | 40 | ||
| 7383310 | 36.9 (UC) | 95.8 (UC) | 5.50 | >2.73 | 20 | ||
| 7407367 | 142.3 (UC) | 141.3 (UC) | 7.45 | >2.01 | >28 | ||
| 7409994 | 6.46 (UC) | 3.36 (UC) | 3.27 | >4.59 | >128 | ||
| 7577905 | 243.6 (NC) | 151.4 (C) | 2.35 | >6.37 | 48 | ||
| 7610600 | 34.6 (UC) | 29.2 (UC) | 1.65 | >9.11 | >96 | ||
| 7622922 | 136.5 (UC) | 804.8 (UC) | 1.84 | >8.14 | >128 | ||
| 7741101 | 42.9 (UC) | 72.1 (UC) | 5.47 | >7.31 | >128 | ||
| 7741703 | 24.7 (UC) | 24.8 (UC) | 3.29 | >4.56 | 48 | ||
| 7756985 | 96.6 (UC) | 207.4 (UC) | 0.80 | >18.66 | 4 | ||
| 7759844 | 0.603 (UC) | 0.233 (UC) | 0.63 | >23.70 | 8 | ||
| 7913222 | 126.0 (UC) | 92.3 (UC) | 6.27 | >2.39 | 64 | ||
| 9008726 | 31.0 (UC) | 44.0 (UC) | 4.26 | >15 | NA |
SI defined as 
i.e. the ratio of vero cell cytotoxicity to the anti-TB activity.
Note: (UC) stands for Uncompetitive inhibition, (NC) Noncompetitive, (C) Competitive, (NA) Not available and (SI) Selectivity index.