Table 3. Statistical analysis of the functional abundance and diversity of the D-box and the KEN-box proteins in H. sapiens.
| Description of GO term | D- or KEN-box | Proteome | E-ratioc | p-value | ||
| Num.a | Per.b | Num. | Per. | |||
| The top 15 most enriched biological processes in D-box proteins | ||||||
| Regulation of small GTPase mediated signal transduction (GO:0051056) | 70 | 2.02% | 169 | 0.92% | 2.18 | 1.19E-11 |
| Protein phosphorylation (GO:0006468) | 116 | 3.34% | 371 | 2.03% | 1.65 | 7.27E-09 |
| Regulation of Rho protein signal transduction (GO:0035023) | 35 | 1.01% | 72 | 0.39% | 2.56 | 1.20E-08 |
| Microtubule-based movement (GO:0007018) | 39 | 1.12% | 93 | 0.51% | 2.21 | 2.74E-07 |
| Axon guidance (GO:0007411) | 93 | 2.68% | 303 | 1.66% | 1.62 | 5.54E-07 |
| Intracellular signal transduction (GO:0035556) | 82 | 2.36% | 269 | 1.47% | 1.61 | 3.40E-06 |
| G2/M transition of mitotic cell cycle (GO:0000086) | 41 | 1.18% | 110 | 0.60% | 1.96 | 5.28E-06 |
| Mitotic cell cycle (GO:0000278) | 90 | 2.59% | 306 | 1.67% | 1.55 | 5.95E-06 |
| Intracellular protein kinase cascade (GO:0007243) | 35 | 1.01% | 89 | 0.49% | 2.07 | 6.38E-06 |
| Cell adhesion (GO:0007155) | 141 | 4.06% | 546 | 2.99% | 1.36 | 4.11E-05 |
| Positive regulation of Rho GTPase activity (GO:0032321) | 13 | 0.37% | 23 | 0.13% | 2.98 | 6.84E-05 |
| Peptidyl-serine phosphorylation (GO:0018105) | 20 | 0.58% | 45 | 0.25% | 2.34 | 8.14E-05 |
| Mitotic metaphase/anaphase transition (GO:0007091) | 9 | 0.26% | 13 | 0.07% | 3.65 | 1.08E-04 |
| Nerve growth factor receptor signaling pathway (GO:0048011) | 63 | 1.82% | 215 | 1.18% | 1.54 | 1.56E-04 |
| Regulation of glucose transport (GO:0010827) | 15 | 0.43% | 31 | 0.17% | 2.55 | 1.98E-04 |
| The top 15 most enriched biological processes in KEN-box proteins | ||||||
| Cell cycle (GO:0007049) | 71 | 5.56% | 416 | 2.28% | 2.44 | 1.64E-12 |
| Cell division (GO:0051301) | 50 | 3.92% | 267 | 1.46% | 2.68 | 1.20E-10 |
| Mitotic cell cycle (GO:0000278) | 54 | 4.23% | 306 | 1.67% | 2.53 | 2.21E-10 |
| M phase of mitotic cell cycle (GO:0000087) | 26 | 2.04% | 93 | 0.51% | 4.00 | 5.69E-10 |
| Microtubule-based movement (GO:0007018) | 24 | 1.88% | 93 | 0.51% | 3.70 | 1.48E-08 |
| Flavonoid metabolic process (GO:0009812) | 8 | 0.63% | 11 | 0.06% | 10.41 | 7.55E-08 |
| Mitosis (GO:0007067) | 33 | 2.59% | 181 | 0.99% | 2.61 | 3.22E-07 |
| Golgi to plasma membrane protein transport (GO:0043001) | 6 | 0.47% | 7 | 0.04% | 12.27 | 7.55E-07 |
| Flavone metabolic process (GO:0051552) | 5 | 0.39% | 5 | 0.03% | 14.32 | 1.65E-06 |
| Sulfation (GO:0051923) | 6 | 0.47% | 8 | 0.04% | 10.74 | 2.84E-06 |
| Mitotic prometaphase (GO:0000236) | 19 | 1.49% | 85 | 0.47% | 3.20 | 4.81E-06 |
| Cell adhesion (GO:0007155) | 64 | 5.02% | 546 | 2.99% | 1.68 | 3.08E-05 |
| G2/M transition of mitotic cell cycle (GO:0000086) | 20 | 1.57% | 110 | 0.60% | 2.60 | 6.78E-05 |
| Axon guidance (GO:0007411) | 40 | 3.13% | 303 | 1.66% | 1.89 | 7.58E-05 |
| Protein targeting to lysosome (GO:0006622) | 5 | 0.39% | 8 | 0.04% | 8.95 | 7.72E-05 |
The top15 most over-represented biological processes are shown.
a
the number of proteins annotated;
b
the proportion of proteins annotated;
c
E-ratio, enrichment ratio, the D-box or KEN-box proportion divided by the human proteome proportion.