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. 2012 Mar 29;7(3):e34333. doi: 10.1371/journal.pone.0034333

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Choi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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ICP-AES analysis of Gd in the blood after tail vein injection of the Gd-C₅F₁₂-PLNs showed that plasma half-life of Gd-C₅F₁₂-PLN-30 was 2.49±1.27 (A), Gd-C₅F₁₂-PLN-50 was 1.54±0.29 (B), and Gd-C₅F₁₂-PLN-100 was 1.58±0.17 (C). The body distribution of Gd-C₅F₁₂-PLNs was determined by [Gd] quantified by ICP-AES 24 hours after administering Gd-C₅F₁₂-PLNs in mice (D).