Table 3. Cumulative Frequencies of Selected Mutations within the rrs Gene among Mycobacterium tuberculosis Isolates Resistant or Susceptible to Amikacin (AMK), Kanamycin (KAN) and/or Capreomycin (CAP).

Mutation	Drug Tested	#R Examined	#S Examined	#R with Mutation	#S with Mutation	Frequency of Mutation among R	Frequency of Mutation among S
A1401G	AMK	493	703	387	0	0.78	0.00
	KAN	637	643	354	0	0.56	0.00
	CAP	483	678	367	45	0.76	0.07
A514C	AMK	200	263	20	15	0.10	0.06
	KAN	269	236	23	12	0.09	0.05
	CAP	195	273	14	14	0.07	0.05
C517T	AMK	200	263	14	10	0.07	0.04
	KAN	269	236	20	5	0.07	0.02
	CAP	195	273	8	14	0.04	0.05
A513C	AMK	196	260	1	1	0.01	0.00
	KAN	259	239	9	4	0.03	0.02
	CAP	190	271	1	1	0.01	0.00
G1484T	AMK	491	666	5	1	0.01	0.00
	KAN	616	654	9	0	0.01	0.00
	CAP	483	678	2	0	0.00	0.00
C1402T	AMK	443	624	3	6	0.01	0.01
	KAN	525	543	5	4	0.01	0.01
	CAP	434	637	7	0	0.02	0.00
G1158T	AMK	206	133	2	0	0.01	0.00
	KAN	273	116	2	0	0.01	0.00
	CAP	201	149	2	0	0.01	0.00
A907C	AMK	200	263	2	1	0.01	0.00
	KAN	259	236	2	1	0.01	0.00
	CAP	190	271	1	1	0.01	0.00
C1402	AMK	443	624	0	1	0.00	0.00
	KAN	525	543	3	0	0.01	0.00
	CAP	434	637	1	0	0.00	0.00

R = Resistant isolates.

S = Susceptible isolates.