Table 4. Cumulative Frequencies of Selected Mutations within the tlyA Gene among Mycobacterium tuberculosis Isolates Resistant or Susceptible to Amikacin (AMK), Kanamycin (KAN) and/or Capreomycin (CAP).

Mutation	Drug Tested	#R Examined	#S Examined	#R with Mutation	#S with Mutation	Frequency of Mutation among R	Frequency of Mutation among S
insGT755	AMK	257	221	2	9	0.01	0.04
	KAN	223	118	9	2	0.04	0.02
	CAP	366	559	11	0	0.03	0.00
G223T	AMK	257	184	2	0	0.01	0.00
	KAN	223	118	2	0	0.01	0.00
	CAP	366	559	2	0	0.01	0.00
insGC202	AMK	257	221	0	0	0.00	0.00
	KAN	223	118	0	0	0.00	0.00
	CAP	366	559	2	0	0.01	0.00
Gly196Glu*	AMK	257	221	0	0	0.00	0.00
	KAN	223	118	0	0	0.00	0.00
	CAP	366	559	2	0	0.01	0.00
T220C	AMK	257	221	0	0	0.00	0.00
	KAN	223	118	0	0	0.00	0.00
	CAP	366	559	2	0	0.01	0.00
T708G	AMK	257	221	0	3	0.00	0.01
	KAN	223	118	0	3	0.00	0.03
	CAP	366	559	3	0	0.01	0.00

^*Represents an amino acid change, as specific nucleotide changes were not provided for this mutation.

R = Resistant isolates.

S = Susceptible isolates.