Table 1.
Question | Method | Responses* | Votes | |
---|---|---|---|---|
1-initial vote | What criteria should be used to decide that a patient has improved and a taper can proceed? | Sticker vote | Physician judgment based on core set (improvement/unacceptable toxicity) | 50 |
Strength improved or normal | 23 | |||
1-final vote | What criteria should be used to decide that a patient has improved and a taper can proceed? | Hand vote | Patient improved or unacceptable toxicity (defined as strength improved or normal AND enzymes improved or normal AND rash stable/improved/absent AND additional criteria consistent improvement) | 25 |
Physician judgment based on core set improvement or unacceptable toxicity | 1 | |||
2-initial vote | When should first taper of prednisone be attempted (assuming patient has met improvement criteria)? | Sticker vote | 4 weeks | 60 |
When 1st meets improvement criteria | 48 | |||
2-final vote | When should first taper of prednisone be attempted (assuming patient has met improvement criteria)? | Hand vote | 4 weeks | 20 |
When 1st meets improvement criteria | 4 | |||
3-initial vote | At what interval should prednisone be tapered? | Sticker vote | Every 2 weeks from 2-0.5mg/kg, then every 4 weeks | 43 |
Ever 2 – 4 weeks | 25 | |||
Every 4 weeks, then when less than 0.2 mg/kg every 8 weeks | 24 | |||
Every 2 weeks | 20 | |||
3-second vote | At what interval should prednisone be tapered? | Sticker vote | Ever 2 weeks at 2-0.5mg/kg, then q4 wks | 66 |
Every 2 weeks | 29 | |||
Every 4 weeks at 2.0-0.2 mg/kg, then every 8 weeks | 28 | |||
3-final vote | At what interval should prednisone be tapered? | Hand vote | Every 2 weeks at 2-0.5mg/kg, then q4 wks | 24 |
Disagree | 3 | |||
4-initial vote | By what dose should prednisone be tapered at each taper step? | Sticker vote | 20% of current dose | 56 |
10% of current dose | 38 | |||
0.25mg/kg x4, 0.125mg/kg x4, then 0.05mg/kg x4 to 5mg, then off | 15 | |||
5 | When should children come off corticosteroids? | No voting | 4–8 months | n/a |
>12 months | n/a | |||
6 | What criteria should be used to decide that a patient is unchanged? | Hand vote | Not improved and not worse (physician judgment | 19 |
Physician judgment | 1 | |||
Physician and parent judgment (combined) | 1 | |||
7-initial vote | What should be done when a patient meets criteria for being unchanged (assuming patient is not in remission)? | Sticker vote | Hold dose for 4 weeks, then escalate therapy if still unchanged | 45 |
Physician judgment | 38 | |||
7-final vote | What should be done when a patient meets criteria for being unchanged (assuming patient is not in remission)? | Hand vote | Hold dose for 4 weeks, then escalate therapy if still unchanged | 14 |
Physician judgment | 3 |
only responses with substantial support