Table 4.
Cohort | Standardized Incidence Ratios for All Malignancy (95% CI) | ||
---|---|---|---|
All Identified Incident Malignancies | Probable and Highly Probable Incident Malignancies | Highly Probable Cases Incident Malignancies | |
All children with JIA | 3.3 (1.6–6.1) | 4.4 (1.8–9.0) | 3.3 (0.9–8.5) |
JIA unexposed | 4.6 (1.7–10) | 6.9 (2.3–16) | 6.2 (1.4–17) |
JIA MTX without TNF inhibitor | 3.3 (0.7–9.5) | 3.9 (0.4–14) | 2.3 (0.01–14) |
JIA any TNF inhibitor | 1.6 (0.03–8.3) | 0 (0–9.7) | 0 (0–13) |
Highly probable was defined as >2 ICD-9 codes for the same form of malignancy and evidence of cancer treatment. Probable was defined as >2 ICD-9 codes for the same malignancy over a period of more than 1 month OR ≤ 2 ICD-9 codes for the same malignancy and evidence of cancer treatment.
JIA = juvenile idiopathic arthritis; ADHD = attention-deficit hyperactivity disorder; MTX = methotrexate or leflunomide; TNF inhibitor = etanercept, infliximab, or adalimumab; ICD-9 = International Classification of Disease, Ninth Revision