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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Bioorg Chem. 2011 Nov 27;43:37–43. doi: 10.1016/j.bioorg.2011.11.005

Fig. 1. Structures of thymidylate synthases.

Fig. 1

(A) Classical thymidylate synthase dimer from E. coli (PDB ID 2KCE). The dUMP substrate is red and the CH2H4folate analog (Zd 1694, Raltitrexed) is magenta, shown as space filling shapes. (B) Flavin-dependent thymidylate synthase tetramer from T. maritima (PDB ID 1O26). FAD prosthetic group is blue and dUMP is red.