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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Bioorg Chem. 2011 Nov 27;43:37–43. doi: 10.1016/j.bioorg.2011.11.005

Scheme 2. Reactions catalyzed by thymidylate synthases.

Scheme 2

(A) The overall reaction catalyzed by classical TSase. The atoms of importance are numbered. (B) The overall reaction catalyzed by FDTS. R=2′-deoxyribose-5′-phosphate; R′=(p-aminobenzoyl)-glutamate; R″=adenosine-5′-pyrophosphate-ribityl. Reproduced with permission from ref. 28.