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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Bioorg Chem. 2011 Nov 27;43:37–43. doi: 10.1016/j.bioorg.2011.11.005

Scheme 4. Mechanism of inhibition of SAM- and folate-dependent uracil methyltransferases by 5-fluorouridylate.

Scheme 4

(A) Mechanism of formation of an inhibitory covalent complex in CH2H4folate-dependent enzymes (classical TSase and TrmFO). (B) Mechanism of formation of an inhibitory covalent complex in SAM-dependent enzymes (RumA and TrmA). SAM = S-adenosylmethionine; SAH = S-adenosylhomocysteine.