| Nomenclature | α8* (avian) | α9* |
|---|---|---|
| Previous names | Neuronal, α-bungarotoxin-sensitive | – |
| Selective agonists | – | – |
| Selective antagonists | – | (α9)5: α-bungarotoxin, strychnine, nicotine, muscarine |
| α9α10: α-contoxin RgIA, α-bungarotoxin, strychnine, nicotine, muscarine | ||
| Commonly used antagonists | (α8)5: α-bungarotoxin > atropine ≥ (+)-Tc ≥ strychnine | (α9)5: α-bungarotoxin > methyllycaconitine > strychnine ∼ tropisetron > (+)-Tc |
| α9α10: α-bungarotoxin > tropisetron = strychnine > (+)-Tc | ||
| Channel blockers | – | – |
| Radioligands (Kd) | [3H]-epibatidine ((α8)5, 0.2 nM) | [3H]-methyllycaconitine (hα9α10, 7.5 nM) |
| [3H]/[125I]-α-bungarotoxin (native α8*, 5.5 nM) | [3H]/[125I]-α-bungarotoxin | |
| Functional characteristics | – | (α9)5: PCa/PNa = 9; α9α10: PCa/PNa = 9, Pf = 22% |
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