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. 2011 Nov;164(Suppl 1):S115–S135. doi: 10.1111/j.1476-5381.2011.01649_4.x
Nomenclature NMDA
Ensembl Gene family ID ENSF00000000436
Selective agonists (glutamate site) NMDA (GluN2D > GluN2C > GluN2B > GluN2A), L-aspartate (GluN2D = GluN2B > GluN2C = GluN2A), D-aspartate (GluN2D > GluN2C = GluN2B > GluN2A), (RS)-(tetrazol-5-yl)glycine (GluN2D > GluN2C = GluN2B > GluN2A), homoquinolinic acid (GluN2B ≥ GluN2A ≥ GluN2D > GluN2C; partial agonist at GluN2A and GluN2C)
Selective antagonists (glutamate site) d-AP5, CGS19755 (selfotel), CGP37849, LY233053, d-CCPene (GluN2A = GluN2B > GluN2C = GluN2D), UBP141 (GluN2D > GluN2D > GluN2A > GluN2A, Morley et al., 2005), NVP-AAM077 (GluN2A > GluN2B (human), Auberson et al. 2002; but weakly selective for rat GluN2A versus GluN2B Feng et al., 2004; Frizelle et al., 2006; Neyton and Paoletti, 2006), conantokin-G (GluN2B > GluN2D = GluN2C = GluN2A)
Selective agonists (glycine site) Glycine (GluN2D > GluN2C > GluN2B > GluN2A), D-serine (GluN2D > GluN2C > GluN2B > GluN2A), (+)-HA966 (partial agonist, GluN2B > GluN2A)
Selective antagonists (glycine site) 5,7-Dichlorokynurenate, L689560, L701324, GV196771A
Channel blockers Mg2+ (GluN2A = GluN2B > GluN2C = GluN2D), (+)-MK801, ketamine, phencyclidine, memantine (GluN2C ≥ GluN2D ≥ GluN2B > GluN2A), amantidine (GluN2C = GluN2D ≥ GluN2B ≥ GluN2A), N1-dansyl-spermine (GluN2A = GluN2B >> GluN2C = GluN2D)
Probes
Glutamate site [3H]CPP, [3H]CGS19755, [3H]CGP39653
Glycine site [3H]Glycine, [3H]L689560, [3H]MDL105519, [3H]CGP61594 (photoaffinity ligand)
Cation channel [3H]-MK801 (dizocilpine)