Ensembl Gene family ID |
ENSF00000000436 |
Selective agonists (glutamate site) |
NMDA (GluN2D > GluN2C > GluN2B > GluN2A), L-aspartate (GluN2D = GluN2B > GluN2C = GluN2A), D-aspartate (GluN2D > GluN2C = GluN2B > GluN2A), (RS)-(tetrazol-5-yl)glycine (GluN2D > GluN2C = GluN2B > GluN2A), homoquinolinic acid (GluN2B ≥ GluN2A ≥ GluN2D > GluN2C; partial agonist at GluN2A and GluN2C) |
Selective antagonists (glutamate site) |
d-AP5, CGS19755 (selfotel), CGP37849, LY233053, d-CCPene (GluN2A = GluN2B > GluN2C = GluN2D), UBP141 (GluN2D > GluN2D > GluN2A > GluN2A, Morley et al., 2005), NVP-AAM077 (GluN2A > GluN2B (human), Auberson et al. 2002; but weakly selective for rat GluN2A versus GluN2B Feng et al., 2004; Frizelle et al., 2006; Neyton and Paoletti, 2006), conantokin-G (GluN2B > GluN2D = GluN2C = GluN2A) |
Selective agonists (glycine site) |
Glycine (GluN2D > GluN2C > GluN2B > GluN2A), D-serine (GluN2D > GluN2C > GluN2B > GluN2A), (+)-HA966 (partial agonist, GluN2B > GluN2A) |
Selective antagonists (glycine site) |
5,7-Dichlorokynurenate, L689560, L701324, GV196771A |
Channel blockers |
Mg2+ (GluN2A = GluN2B > GluN2C = GluN2D), (+)-MK801, ketamine, phencyclidine, memantine (GluN2C ≥ GluN2D ≥ GluN2B > GluN2A), amantidine (GluN2C = GluN2D ≥ GluN2B ≥ GluN2A), N1-dansyl-spermine (GluN2A = GluN2B >> GluN2C = GluN2D) |
Probes |
|
Glutamate site |
[3H]CPP, [3H]CGS19755, [3H]CGP39653
|
Glycine site |
[3H]Glycine, [3H]L689560, [3H]MDL105519, [3H]CGP61594 (photoaffinity ligand) |
Cation channel |
[3H]-MK801 (dizocilpine) |