Fig. 1.

Method for calculation of time-lag to fulfill RIFLE (risk of renal dysfunction, injury to the kidney, failure or loss of kidney function, end stage renal disease) criteria. The grey marker reaches "RIFLE R" on day + 1 (arrow), which defines the start of the episode. The mean concentration of day –2 to day 0 is used as baseline for calculation of the time-lag. In the example, "RIFLE F" is reached on day +3 by the marker presented in grey and on day +4 by the black marker