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. Author manuscript; available in PMC: 2013 Mar 20.
Published in final edited form as: Cancer Cell. 2012 Mar 20;21(3):362–373. doi: 10.1016/j.ccr.2012.02.010

Figure 8. ALK inhibits a developmentally-timed apoptotic response triggered by MYCN overexpression in the interrenal gland.

Figure 8

(A) Numbers of Hu+ interrenal gland cells in the DβH, ALK, MYCN and MYCN;ALK fish at 5.5 wpf. Means of Hu+ cell numbers were compared by the two-tailed Wilcoxon signed-rank test.

(B) Numbers of apoptotic Hu+ interrenal gland cells in the DβH, ALK, MYCN and MYCN;ALK fish at 5.5 wpf. The numbers of transgenic fish at 5.5 wpf with apoptotic Hu+ cells in the interrenal gland were compared by two-tailed Fisher exact test.

(C) Sagittal sections through the interrenal gland in MYCN (top panels) and MYCN;ALK (bottom panels) transgenic fish at 5.5 wpf (dorsal up, anterior left). Hu, green; activated Caspase-3, red. Hu+, activated Caspase-3+ apoptotic cells were detected in the MYCN transgenic fish (arrowheads). Dotted lines indicate the head kidney (HK) boundary. Scale bars, 10 μm.

See also Figure S7.