Fig. 1.
Parameters affecting noise propagation. Activator input noise is converted to external noise (ηext) in target gene transcription based on Equation (10) in a simplified gene regulatory model. Here, ηext is shown as a function of ρi, the mean number of active copies. The effects of parameters that affect noise propagation are also shown. Such parameters include the activator noise strength (v), the activator threshold concentration (K) and the Hill coefficient (h). Figure 1A shows that ηext increases as the normalized noise strength (v/K) increases. Figure 1B shows that, at a given v/K, the effect of h on ηext is sensitive to ρ.