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State of methylation of the promoter-enhancer region (600 bp) of the reporter gene in cell lines containing the empty vector (Top), the vector and 5-MCDG (Middle), and the vector and an inactive mutant of 5-MCDG (Bottom). For one cell line (HGC2 from Fig. 6), the bisulfite genomic sequencing of individual clones is shown. Solid circles are methylated CpGs, and vertical bars without circle are nonmethylated CpGs. TSS, transcription start site.
