Figure 1.

Overview of KSHV induction of angiogenic and lymphangiogenic pathways. Pro-angiogenic factors that are induced by KSHV are indicated in red ovals, pro-lymphangiogenic factors induced by KSHV are indicated in blue ovals. White ovals indicate the activated pathway necessary for KSHV induction of blood to lymphatic endothelial cell differentiation. KSHV genes known to induce angiogenic or lymphangiogenic pathways are indicated in green ovals. The upper left corner indicates phenotypes of angiogenesis that are activated in normal endothelium by KSHV-infected cells and the gradient of cytokines secreted by KSHV-infected cells is indicated by the red gradient. The blue gradient in the upper right hand corner indicates the gradient of lymphangiogenic cytokines induced by KSHV-infected cells that could induce lymphangiogenesis. The central box indicates angiogenic phenotypes induced by KSHV in a cell autonomous fashion.