Table 1.

KSHV genes involved in the induction of angiogenesis.

KSHV gene	Pro-angiogenic effect
Glycoprotein B	Increased VEGF-A secretion
K8.1	Increased VEGF-A secretion
Kl	Increased VEGF-A secretion; Disrupted VE-cadherin signaling
LANA-1	HIF-1 stability
vIRF3	HIF-1 stability
vGPCR	HIF-1 stability; Increased VEGF-A secretion; Increased angiopoietin-1 secretion; Increased angiopoietin-like 4 secretion; Disrupted VE-cadherin signaling
vIL-6	Increased VEGF-A secretion; Increased angiopoietin-1 secretion
Viral miRNAs	Downregulation of thrombospondin-1
vMIPs I–III	Chemoattraction
K5	Degradation of VE-cadherin; Degradation of PECAM-1