Table 2.
Endocrine evaluation results and diagnostic considerations19
| LABORATORY TEST | PLASMA HORMONE LEVEL (ng/dL) | SUSPECTED DIAGNOSIS |
|---|---|---|
| DHEAS* | •Elevated >8000 | •Adrenal tumor |
| •Elevated 4000—8000 | •Congenital adrenal hyperplasia (CAH) | |
| •Elevated >700 | •Androgen-secreting tumor | |
| •Normal/slightly elevated | •Polycystic ovarian syndrome (PCOS); •Cushing syndrome |
|
| TOTAL TESTOSTERONE | •>200 | • Ovarian androgensecreting tumor |
| •100—200 | • PCOS •CAH •Cushing syndrome |
|
| FREE TESTOSTERONE | • Elevated from normal range | • Hyperandrogenism |
| LH:FHS RATIO# | •>2:3 | • PCOS |
| • Normal | • CAH •Adrenal tumor • Cushing syndrome • Androgen-secreting tumor |
|
| •17-HYDROXYPROSTERONE | • Elevated >200 | • Late-onset congenital adrenal hyperplasia |
| • Normal/increased | • PCOS • Adrenal tumor •Cushing syndrome • Androgen-secreting tumor |
*
DHEAS: dehydroepiandrosterone sulfate
#
LH:FSH ratio: leutinizing hormone:follicle-stimulating hormone ratio