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. 2001 Apr 17;98(9):5049–5054. doi: 10.1073/pnas.081547998

Figure 5.

Figure 5

XIAP inhibits dexamethasone-induced apoptotsis in vivo. (A) Total thymocytes recovered 48 h after treatment with 0.05 mg [lckpr-xiap lines 1 (n = 20, P < 0.01) and line 2 (n = 18, P < 0.01)] or 0.25 mg [lckpr-xiap lines 1 (n = 20, P < 0.01)] of dexamethasone i.p. All mice used were between 4 and 5 weeks old. (B) Two-color flow cytometry contour plots of CD4 and CD8 expression on surviving thymocytes from lckpr-xiap line 1 and wild-type mice. The surviving 0.25 mg dexamethasone- or saline-treated thymocytes were doubly stained with anti-CD4-phycoerythrin and CD8a-Cy-Chrome. The percentages of the T cell subpopulations given are the average from all of the mice used in the corresponding experiment.