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XIAP inhibits Fas-induced apoptosis in vivo. Total lckpr-xiap lines 1 (n = 24, P < 0.01) and wild-type thymocytes undergoing apoptosis 2 h after treatment with 100 μg of clone Jo2 anti-Fas antibody i.p. (A). All mice used were between 4 and 5 weeks old. (B) Agarose gel electrophoresis of DNA extracted from the livers of anti-Fas treated wild-type (WT) and lckpr-xiap line 1 mice (100 μg, 2 h) and nontreated saline-injected control mice.
