Gag targeting and infecting HIV-1 clade. The frequency of recognition of consensus group M Gag peptides is compared in clade A (n=20) and D (n=24) infection. Gag T cell recognition clustered in eight regions: Gag17–47 (p17-I), Gag74–95 (p17-II), Gag140–194 (p24-I), Gag196–218 (p24-II), Gag245–283 (p24-III), Gag290–381 (p24-IV), Gag290–381 (p24-V), and Gag429–447 (p15-I). Overall recognition of Gag clusters (A) and recognition by clade A1- (B) and D-infected (C) individuals are illustrated.