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Changes from baseline in fatty acid amide hydrolase substrates determined using mixed effects repeated measures model analysis (adjusted for baseline). (a) Anandamide (AEA) in serum. (b) Oleoylethanolamide (OEA) in serum. (c) Palmitoylethanolamide (PEA) in serum. Data show predicted means and s.e. at each weak. Statistical significance is calculated between groups (†P⩽0.05, ††P⩽0.01 and †††P⩽0.001) and vs baseline (that is, 0; *CBD, #AMI; ***/###P⩽0.05, **/##P⩽0.01, */#P⩽0.001).
