Table 1. Baseline description of full analysis set (modified intention-to-treat).
| Cannabidiol (n=20) | Amisulpride (n=19) | P-valuea | |
|---|---|---|---|
| Demographic characteristics, mean (s.d.) | |||
| Age, years | 29.7 (8.3) | 30.6 (9.4) | 0.966 |
| Weight, kg | 81.8 (16.0) | 73.3 (11.4) | 0.106 |
| Pulse, beats/min | 83.4 (12.7)b | 86.3 (14.2) | 0.490 |
| Blood pressure, mm Hg | |||
| Diastolic | 80.8 (9.2) | 77.3 (7.1) | 0.224 |
| Systolic | 123.8 (15.5) | 119.2 (13.1) | 0.394 |
| Male gender, count (%) | 15 (75) | 17 (89) | 0.407 |
| Baseline severity of illness scores, mean (s.d.) | |||
| PANSS | |||
| Total | 91.2 (14.0) | 95.5 (17.1) | 0.736 |
| Positive | 24.6 (5.6) | 22.5 (6.2) | 0.205 |
| Negative | 23.7 (5.4) | 25.3 (5.6) | 0.573 |
| General | 42.9 (8.6) | 47.7 (11.4) | 0.155 |
| Factor 1 | 16.3 (4.8) | 15.9 (5.6) | 0.554 |
| Factor 2 | 20.2 (4.8) | 21.8 (5.3) | 0.516 |
| Factor 3 | 10.0 (2.6) | 11.2 (3.4) | 0.134 |
| Factor 4 | 12.6 (2.7) | 11.8 (4.1) | 0.592 |
| Factor 5 | 10.0 (4.0) | 10.7 (3.4) | 0.489 |
| BPRS | 58.1 (9.7) | 57.7 (10.3) | 0.746 |
| CGI severity | 6.3 (0.7) | 6.8 (0.4) | 0.011 |
| Other, mean (s.d.) | |||
| Lorazepam, mg/day | 2.2 (1.6) | 4.2 (2.4) | 0.006 |
| SAS | 36.4 (7.7) | 36.9 (8.1) | 0.800 |
| EPS | 0.1 (0.2) | 0.0 (0.1) | 0.485 |
Abbreviations: BPRS, Brief Psychiatric Rating Scale; CGI, Clinical Global Impression Scale; EPS, Extrapyramidal Symptoms Rating Scale; PANSS, Positive and Negative Syndrome Scale; SAS, Social Anxiety Scale.
a
The Wicoxon rank sum test or Fisher's exact test.
b
n=19.
Bold indicates statistical significance between groups (P⩽0.05).