Table 2.
Interactions between PPARA and inflammation-related cytokines
| PPARA genotype | Cytokine genotype | Synergy factor (95% confidence interval, p) | ||
|---|---|---|---|---|
| Overall | North Europe† | North Spain† | ||
| rs1800206 | IL1A rs3783550 | 1.6 (1.05-2.3, 0.03) | 1.3 (0.8-2.1, 0.26) | 2.0 (0.9-4.4, 0.10) |
| CC vs CG + GG | AA vs AC + CC | |||
| IL1B rs16944 | 1.9 (1.05-3.4, 0.03) | 1.7 (0.85-3.25, 0.14) | 1.8 (0.5-6.7, 0.38) | |
| GG + GA vs AA | ||||
| IL10 rs1800896 | 1.6 (0.998-2.5, 0.051) | 1.7 (1.03-2.8, 0.04) | 1.7 (0.5-5.9, 0.40) | |
| GA + AA vs GG | ||||
| rs 4253766 | IL1A rs3783550 | 1.6 (1.15-2.2, 0.005) | 1.7 (1.2-2.5, 0.006) | 1.5 (0.7-3.0, 0.27) |
| CC vs CT + TT | AC + CC vs AA | |||
| IL10 rs1800896 | 1.5 (1.03-2.2, 0.035) | 1.4 (0.9-2.1, 0.18) | 1.9 (0.9-4.1, 0.09) | |
| AA vs GA + GG | ||||
| rs135551 | IL1B rs16944 | 1.3 (0.99-1.7, 0.06) | 1.3 (0.96-1.8, 0.09) | 1.4 (0.75-2.5, 0.32) |
| GG vs GA + AA | GG vs GA + AA | |||
†
North Europe here comprises Bonn, Bristol, Nottingham, Oxford and Rotterdam; North Spain comprises Oviedo and Santander Nominally significant interactions are in bold;
SNP = single nucleotide polymorphism; PPARA, IL1A, IL1B and IL10 are the genes for peroxisome proliferator-activated receptor-α, interleukin-1α, interleukin-1β and interleukin-10, respectively.